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Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: a TMS study. |
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| Authors: | Stefano Tamburin Antonio Fiaschi Domenico Idone Piergiorgio Lochner Paolo Manganotti Giampietro Zanette |
| Affiliation: | Department of Neurological Sciences and Vision, Section of Neurological Rehabilitation, University of Verona, Verona, Italy. stefano.tamburin@mail.univr.it |
| Abstract: | Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms. |
| Keywords: | Parkinson's disease bradykinesia sensorimotor integration motor evoked potentials digital nerve stimulation transcranial magnetic stimulation |