Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors |
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| Authors: | van Etten B Eggermont A M M Ambagtsheer G van Tiel S T ten Hagen T L M |
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| Affiliation: | Erasmus University Medical Centre-Daniel den Hoed Cancer Centre, Department of Surgical Oncology, PO Box 5201, 3008 AE Rotterdam, The Netherlands. |
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| Abstract: | ![]()
Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings. |
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| Keywords: | gene therapy adenovirus antibodies liver perfusion |
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