| RESPONSIVENESS OF Smad7 GENE TO TGF-b1 IN THE TUMORIGENESIS |
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| 引用本文： | 霍艳英,张开泰,李邦印,段瑞峰,范保星,项小琼,胡迎春,谢玲,吴德昌. RESPONSIVENESS OF Smad7 GENE TO TGF-b1 IN THE TUMORIGENESIS[J]. 中国癌症研究, 2002, 0(3) |
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| 作者姓名： | 霍艳英 张开泰 李邦印 段瑞峰 范保星 项小琼 胡迎春 谢玲 吴德昌 |
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| 作者单位： | Department of Molecular Toxicology，Beijing Institute of Radiation Medicine Beijing 100850 |
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| 基金项目： | This work was supported by the National ?73?Key Basic Research Program of China (No.G1998051207). |
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| 摘 要： | Transforming growth factor-b (TGF-b) is a potent natural antiproliferative agent that plays an important role in suppressing tumorigenicity. Disruption of TGF-b signaling is implicated in numerous cancers, such as colon-rectal cancer, pancreatic cancer, lung cancer, skin cancer, et al. TGF-b signaling occurs via ligand-initiated complex formation of a heteromeric serine-threonine kinase receptor complex, following which the TGF-b type I receptor is phosphorylated by the constitutively act…
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RESPONSIVENESS OF Smad7 GENE TO TGF-b1 IN THE TUMORIGENESIS |
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| Affiliation: | Department of Molecular Toxicology,Beijing Institute of Radiation Medicine Beijing 100850 |
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| Abstract: | |
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| Keywords: | TGF-b1 Smad7 Tumorigenesis |
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