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Immune reconstitution inflammatory syndrome associated with Aspergillus terreus pulmonary infection in an autologous stem cell transplant recipient |
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| Authors: | S. Antinori M. Corbellino A. Necchi P. Corradini C. Vismara V. Montefusco A.M. Gianni |
| Affiliation: | Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, Universitàdegli Studi di Milano, Milan, Italy;, Medical Oncology 3, IRCCS-Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy;, Bone Marrow Transplant, IRCCS-Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy;, Microbiology Unit, IRCCS-Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy |
| Abstract: | S. Antinori, M. Corbellino, A. Necchi, P. Corradini, C. Vismara, V. Montefusco, A.M. Gianni. Immune reconstitution inflammatory syndrome associated with Aspergillus terreus pulmonary infection in an autologous stem cell transplant recipient. Transpl Infect Dis 2010: 12: 64–68. All rights reserved Abstract: We describe an autologous stem cell transplant recipient who developed immune reconstitution inflammatory syndrome (IRIS) associated with Aspergillus terreus invasive pulmonary infection after recovery from neutropenia. Clinical and radiological worsening of pulmonary invasive aspergillosis coincident with a robust decline of serum galactomannan values and rising neutrophil counts should be interpreted as IRIS and should not require changes to antifungal therapy. |
| Keywords: | Aspergillus terreus immune reconstitution inflammatory syndrome galactomannan stem cell transplant |