地中海贫血的铁负荷状况

地中海贫血是由于血红蛋白的珠蛋白链合成受到部分或完全抑制所引起的一组遗传性溶血性贫血,重型及部分中间型地中海贫血多需反复输血治疗,可导致铁负荷过重,血色病,临床上可出现心肌病、充血性心力衰竭、肝硬化、糖尿病、关节炎、垂体功能减退等。轻型地中海贫血一般不需特殊治疗,比较关注的是其遗传学意义,但是机体铁负荷情况不甚明了,了解其铁负荷情况,对防治可能发生的高铁负荷危害有重要价值。

Iron State in Thalassemia

Thalassemia is a group of hereditary hemolytic anemia,which can cause the synthesis of the globin chain of hemoglobin suffering part or complete suppression,thalassemia major and part of thalassemia intermedia need repeated blood transfusion,which lead to iron overload in their bodies,hemochromatosis,it may result in a series of clinical manifestations,such as cardiomyopathy、congestive cardiac failure、liver cirrhosis、diabetes、arthritis、hypopituitarism,and etc.The thalassemia trait usually needn′t therapy.People often pay close attention to its genetic significance,but its iron state isn,t very clear.Getting the message of the iron state can prevent the patients from the potential dangerousness of possibly iron overload.