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Acyloxyalkoxy-Based Cyclic Prodrugs of Opioid Peptides: Evaluation of the Chemical and Enzymatic Stability as Well as Their Transport Properties Across Caco-2 Cell Monolayers |
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| Authors: | Bak Annette Gudmundsson Olafur S. Friis Gitte J. Siahaan Teruna J. Borchardt Ronald T. |
| Affiliation: | (1) Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, DK-2100 Copenhagen, Denmark;(2) Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, 66047;(3) Present address: Exploratory Biopharmaceutics and Drug Delivery, Bristol-Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, P.O. Box 191, New Brunswick, New Jersey, 08903-0191 |
| Abstract: | |
| Keywords: | esterase-sensitive prodrugs peptide delivery opioid peptides Caco-2 cells chemical and enzymatic stability of peptides |
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