乌司他丁对体外循环术后肺损伤保护作用的临床分析

目的:探讨乌司他丁对体外循环心脏手术后肺功能的保护作用。方法:根据入选标准选择先天性心脏病患儿42例,随机分成对照组(n=20)和乌司他丁组(n=22),观察比较术前、术后1h、24h两组的肺泡-动脉血氧分压差(PA-aO2)、动脉血氧含量(CaO2)、动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)、X胸片、术后带机时间的变化。结果:术前两组各指标基本一致,差别没有统计学意义(P>0.05);乌司他丁组在术后1h及24hPA-aO2较对照组明显降低(P<0.05);乌司他丁组术后1h及24hCaO2,SaO2,PaO2与对照组比较,均较对照组高,差别具有统计学意义(P<0.05);对照组术后胸片渗出较乌司他丁组多;对照组比乌司他丁组带机时间长,差别具有统计学意义(P<0.05)。结论:体外循环过程造成肺损伤,乌司他丁对肺功能具有保护作用。

Protective effect of ulinastatin on lung injury induced by cardiopulmonary bypass

Objective:To study the protective effects of Ulinastatin(UTI)on lung injury after cardiopulmonary bypass.Methods:42 patients with congenital heart disease were randomly divided into two groups,Ulinastatin group(n=22)and control group(n=20).Two groups treated with same therapeutic measure,and UTI group added Ulinastatin 20000 U/kg.Stimultaneous PA-aO2,CaO2,SaO2,PaO2,X-ray chest,Mechanical ventilation time were observed.Results:At pre-operation,these indexes showed no significant difference between two groups(P >0.05);Compared with control group,UTI group PA-aO2 at 1h and 24h postoperation dropped more obviously(P < 0.05),but CaO2,SaO2 and PaO2 had no significant changes.UTI group had a shorter ventilation time,lower simultaneous breath frequency and least rales(P < 0.05).Conclusion:Ulinastatin could protect lung function against injury induced by CPB.