三维适形放疗对食管癌患者的临床疗效观察及血清血管内皮生长因子的变化

目的探讨三维适形放疗(3DCRT)对食管癌患者的临床疗效及血管内皮生长因子(VEGF)的变化水平。方法选取2011年7月-2013年7月十堰市太和医院收治的75例食管癌患者作为研究组,另选体检中心体检的健康人群50例作为对照组。食管癌患者行3DCRT,评价患者的疗效及安全性;采用酶联免疫吸附试验双抗体夹心法检测两组血清VEGF的变化水平,探讨其在放疗中的意义。结果食管癌患者放疗前后血清VEGF水平均显著高于对照组,组间相比,差异有统计学意义(P0.05);食管癌患者放疗4周、放疗后1周血清VEGF水平较放疗前明显降低,差异具有统计学意义(P0.05);放疗有效组放疗4周及放疗后1周血清VEGF水平显著低于放疗前,差异具有统计学意义(P0.05);无效组放疗前后血清VEGF水平相比,差异无统计学意义(P0.05)。结论 3DCRT治疗食管癌疗效确切,不良反应低;VEGF可以作为评估、预测放疗敏感性的生化指标,在食管癌的治疗和预后中有重要意义。

Clinical effects of three dimensional conformal radiotherapy in treatment of patients with esophageal carcinoma and the change of serum vascular endothelial growth factor

Objective To investigate the clinical effects of three dimensional conformal radiotherapy （3DCRT） in treatment of patients with esophageal carcinoma and the change of serum vascular endothelial growth factor （ VEGF）. Methods Seventy-five eases of esophageal cancer patients in the Taihe Hospital of Shiyan City from Jul. 2011 to Jul. 2013 were selected as the study group, another 50 cases of healthy people in health examination center were selected as the control group; esophageal cancer patients were treated with 3DCRT, the efficacy and safety of patients were evaluated. Serum VEGF was detected in two groups by ELISA double antibody sandwich method. Results Serum VEGF level before and after radiotherapy in patients with esophageal carcinoma was higher than that in the control group, the difference was statistically significant （P 〈 0.05） ; in patients with esophageal carcinoma after radiotherapy for 4 weeks, the serum VEGF level was significantly decreased after radiotherapy compared with before radiotherapy （P 〈 0.05） ; the level of serum VEGF of effective radiotherapy group after radiotherapy for 4 weeks was significantly lower compared with before radiotherapy （P 〈 0.05） ; there was no significant difference in the serum levels of VEGF group before and after radiotherapy in ineffective radiotherapy group （P 〉 0.05 ）. Conclusion The effect of 3DCRT for esophageal carcinoma is exact, adverse reactions are low; VEGF can be used to assess and predict radiotherapy sensitivity, it plays an important role in the treatment and prognosis of esophageal carcinoma.