| 硝酸毛果芸香碱眼用凝胶有关物质研究 |
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| 引用本文： | 王伶,张琳,张明臣,谢翀.硝酸毛果芸香碱眼用凝胶有关物质研究[J].齐鲁药事,2008,27(7). |
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| 作者姓名： | 王伶 张琳 张明臣 谢翀 |
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| 作者单位： | 1. 山东省医疗器械研究所,山东,济南,250100
2. 山东胜利股份有限公司,山东,济南,250101 |
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| 摘 要： | 目的建立高效液相色谱法测定硝酸毛果芸香碱眼凝胶有关物质的方法.方法采用C18色谱柱(150mm×4.6mm,5μm),pH=4.5的醋酸盐缓冲液(2.94g醋酸钠与稀醋酸38.4mL加水溶解成600mL,混匀,即得)-甲醇(85∶15)为流动相,检测波长为230nm.结论本方法简便、准确,适用于硝酸毛果芸香碱凝胶的有关物质检查.
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| 关 键 词： | 硝酸毛果芸香碱 有关物质 高效液相色谱法 |
Determination of related substances in pilocarpine nitrate eye gel |
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| Abstract: | OBJECTIVE To establish an HPLC method to determine the related substances of pilocarpine nitrate eye gel.METHODS C18 column(150mm×4.6mm,5μm)was used.The mobile phase consisted of acetate buffer solution-methanol(85∶15).The flow rate was 1.0mL·min.The detection wavelength was 230nm.CONCLUSION This method was simple and accurate for determination of related substances in pilocarpine nitrate. |
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| Keywords: | Pilocarpine nitrate related substance HPLC |
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