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| 大鼠钝性脊髓损伤后BMPR Ia型受体的表达 | |
| 引用本文： | 李华凤,江兴华,邹定全,曹启林,吕静,李媛,张慧芳,王亚平. 大鼠钝性脊髓损伤后BMPR Ia型受体的表达[J]. 南方医科大学学报, 2011, 31(7): 1124-1130 |
| 作者姓名： | 李华凤 江兴华 邹定全 曹启林 吕静 李媛 张慧芳 王亚平 |
| 作者单位： | 四川大学华西第二医院西部妇幼医学研究院发育与疾病实验室麻醉科妇儿疾病与出生缺陷教育部重点实验室;中南大学湘雅二医院麻醉科;The Vivian L Smith Department of Neurosurgery;University of Texas Medical School at Houston; |
| 基金项目： | 国家自然科学基金(81070994); 教育部留学回国人员科研启动基金(教外司留(2009)8号文)~~ |
| 摘 要： | 摘要：目的观察脊髓损伤后BMPR Ia型受体的表达。方法运用免疫组织化学方法，首先检测3种BMP受体（BMPR）Ia、 Ib、II型在正常成体大鼠脊髓中的表达分布。运用大鼠钝性脊髓损伤模型，以150 kdyn的撞击力直接撞击脊髓，观察动物 撞击后1、3、7、14、30、60 d后脊髓中BMPR Ia的表达改变。结果在正常成年大鼠脊髓中，BMPR Ia、II型受体主要在少突 胶质细胞、灰质神经元中表达，在部分星形胶质细胞和大多数小胶质细胞中表达。灰质神经元中未检测到Ib型受体的表 达或表达很低。脊髓损伤后，BMPR Ia在星形胶质细胞中表达激剧增加，高表达可持续至损伤后1个月；脊髓损伤诱导脊 髓小胶质细胞活化，活化的小胶质细胞中表达BMPR Ia明显增加。结论大鼠脊髓损伤后，诱导BMPR Ia受体在星形胶 质细胞、小胶质细胞激剧增加，BMPR Ia高表达提示BMP信号在胶质细胞的重要病理生理作用，这一发现为进一步研究 BMP信号的功能作用提供基础。 |
| 关 键 词： | 脊髓损伤 骨形态发生蛋白受体(IIa、Ib)、II受体 免疫组化 |
Expression of bone morphogenetic protein receptor IA in rats after contusive spinal cord injury |
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| LI Hua-feng,JIANG Xing-hua,ZOU Ding-quan,CAO Qi-lin,L Jing,LI Yuan,ZHANG Hui-fang,WANG Ya-ping. Expression of bone morphogenetic protein receptor IA in rats after contusive spinal cord injury[J]. Journal of Southern Medical University, 2011, 31(7): 1124-1130 | |
| Authors: | LI Hua-feng JIANG Xing-hua ZOU Ding-quan CAO Qi-lin L Jing LI Yuan ZHANG Hui-fang WANG Ya-ping |
| Affiliation: | LI Hua-feng 1,JIANG Xing-hua 2,ZOU Ding-quan 2,CAO Qi-lin 3,Lü Jing 2,LI Yuan 2,ZHANG Hui-fang 2,WANG Ya-ping 2 1 Laboratory of disease and development,Department of Anesthesiology,Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education,West China Institute of Women and Children's Health,West China Second University Hospital,Sichuan University,Chengdu 610041,China,2 Department of Anesthesiology,the Second Xiangya Hospital,Central South University,Ch... |
| Abstract: | Objective To observe the expression pattern of bone morphogenetic protein receptor IA(BMPR IA) in rats after contusive spinal cord injury.Methods The expressions of BMPR IA,IB,and II were detected by immunochemistry in the spinal cord of normal adult rats,and the expression of BMPR IA was detected in the infinite horizons impactor model at 1,3,7,14,30,and 60 days after spinal cord injury.Results In the spinal cord of normal adult rats,BMPR IA and II were expressed predominantly in the oligodentrocytes and n... |
| Keywords: | spinal cord injury bone morphogenetic protein receptors immunohistochemistry |
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