Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12-Dimethylbenz[α]anthracene in Rats on High- and Low-fat Diets |
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| Authors: | Masakuni Noguchi Hirohisa Kitagawa Itsuo Miyazaki Yuji Mizukami |
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| Affiliation: | Department of Surgery (II), Kanazawa University Hospital, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa 920;Operation Center Kanazawa University Hospital, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa 920;Pathology Section, Kanazawa University Hospital, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa 920 |
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| Abstract: | The effects of a high-fat diet and esculetin were investigated on 7,12-dimethylbenz[α]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. Rats were given a 5-mg dose of DMBA. Seven days later, they were fed either a high-fat (20% soybean oil) or low-fat (0.5% soybean oil) diet. A half of the rats received diets containing 0.03% esculetin. Esculetin significantly inhibited tumor incidence, growth and cell kinetics of the tumor in the rats fed the high-fat and the low-fat diets. Our findings indicate that DMBA-induced mammary tumorigenesis is affected by lipoxygenase products. |
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| Keywords: | Esculetin High dietary fat Mammary carcinoma 7,12-Dimethylbenz[α]-anthracene |
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