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Randomised Clinical Trial to Analyse the Efficacy of Eggshell Membrane to Improve Joint Functionality in Knee Osteoarthritis
Authors:Fernando Cá  novas,Marí  a Salud Abellá  n-Ruí  z,Ana Marí  a Garcí  a-Muñ  oz,Antonio Jesú  s Luque-Rubia,Desiré  e Victoria-Montesinos,Silvia Pé  rez-Piñ  ero,Maravilla Sá  nchez-Macarro,Francisco Javier Ló  pez-Romá  n
Affiliation:1.Health Science Department, Campus de los Jerónimos, Universidad Católica San Antonio de Murcia UCAM, 30107 Murcia, Spain; (F.C.); (M.S.A.-R.); (A.M.G.-M.); (A.J.L.-R.); (D.V.-M.); (S.P.-P.); (M.S.-M.);2.Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain
Abstract:
Osteoarthritis is a source of chronic pain and disability. Dietary supplements have been shown to be a more secure option than NSAIDS. Particularly, the eggshell membrane has demonstrated efficacy in relieving joint pain and stiffness. A clinical trial was designed in which three groups were assigned to two different doses of this supplement and compared to a placebo control group. The primary outcome variable was knee pain, which was assessed using a visual analogue scale. Secondary outcome variables were knee functional ability, quadriceps muscle strength (assessed by isometric and isokinetic trials), and quality of sleep. All groups showed a significant decrease in pain perception, although maximum values were obtained in the high-dose group. Isokinetic and isometric trials showed a significant increase in strength in the high-dose group. Eggshell membrane showed the potential to reduce pain and stiffness symptomatology. Here, for the first time, two quantitative variables (mobility and strength of knee joint) were used to accurately evaluate changes in the quality of life of subjects affected by knee joint pain. The results of this study indicate a dose-dependent response, which should be taken into account for later use in therapeutics to establish the correct dosage.
Keywords:knee pain   dietary supplement   stiffness   glycosaminoglycans
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