| HPLC法测定盐酸左氧氟沙星原粉中左氧氟沙星的含量 |
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| 引用本文： | 申东浩,谷肄昊. HPLC法测定盐酸左氧氟沙星原粉中左氧氟沙星的含量[J]. 黑龙江医药, 2009, 22(3): 270-270 |
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| 作者姓名： | 申东浩 谷肄昊 |
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| 作者单位： | 哈药集团医药有限公司,150010;哈药集团医药有限公司,150010 |
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| 摘 要： | 目的：测定盐酸左氧氟沙星原粉中左氧氟沙星的含量。方法：用十八烷基硅烷键合硅胶为填充剂,以己烷磺酸钠溶液[取己烷磺酸钠0.98g,加磷酸盐缓冲液（取磷酸二氢钾6.8g,加水溶解并稀释至1000ml,加0.05ml/l磷酸约500ml使pH值至2.4）1000ml,使溶解,摇匀,即得]-甲醇（3：1）为流动相的高效液相色谱法。结果：回收率99.4%,相对标准偏差0.16%。结论：该方法简便快捷,准确度高,重现性好,适合左氧氟沙星含量的测定。
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| 关 键 词： | 左氧氟沙星 含量 高效液相色谱法 |
Determination of Levofloxacin in the Levofloxacin Hyrochloride Powder by HPLC method |
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| Affiliation: | Shen Donghao (Pharmaceutical Co., L tdofHarbin Pharmaceutical Group(150010) |
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| Abstract: | Objective： To detect the assay of Levofloxacin residual in the Levofloxacin Hyrochloride Powder.Methods：HPLC chromatographic conditions are carried out as following：column is packed with the octadecylsilane chemically bonded silica,flowing phase is composed with ethane sulfonic sodium solution （0.98g ethane sulfonic sodium dissolved in 1000ml phosphate buffer）and methanol（3：1）.Results：the recovery rate is 99.4%,the RSD is 0.16%.Conclusion：the method is operated easily,and has high sensitive and specific,and is suitable to test the assay of Levofloxacin residual. |
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| Keywords: | Levefloxacin assay HPLC |
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