Gas chromatographic determination of glibenclamide in plasma. |
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| Authors: | D Castoldi O Tofanetti |
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| Affiliation: | Research Laboratories of Boehringer Biochemia, Via S. Uguzzone 5, Milan 20126 Italy |
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| Abstract: | ![]()
A gas-chromatographic method for glibenclamide determination in plasma is described. It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard. Characteristics and specificity of the method for the principal metabolite of glibenclamide are examined. |
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| Keywords: | To whom correspondence should be addressed. |
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