马来酸桂哌齐特注射液治疗不稳定型心绞痛的Meta分析

目的 评价马来酸桂哌齐特注射液治疗不稳定型心绞痛的临床疗效. 方法检索并选取国内公开发表的有关马来酸桂哌齐特注射液治疗不稳定型心绞痛的随机对照试验文献,采用Jadad 评分法进行质量评价,运用Meta 分析进行统计分析. 结果 7项研究经Meta分析结果 显示,马来酸桂哌齐特注射液治疗组在减少心绞痛发作次数、改善缺血性心电图方面均优于对照组. 结论 Meta分析结果 显示马来酸桂哌齐特注射液对不稳定型心绞痛有一定疗效,尚需要设计严格、大样本的随机对照试验加以证实.

Meta-analysis of Cinepazide Maleate Injection for Treatment of Unstable Angina Pectoris

Objective To evaluate the efficacy of cinepazide maleate injection for treatment of unstable angina pectoris(UAP).Methods The national and international literatures related to random control clinical trials on cinepazide maleate injection for treating UAP were retrieved.The Jadad score was used to evaluate the quality.The data were statistically analyzed by Meta-analysis.Results It was showed that cinepazide maleate injection was better in reducing frequency of angina attacks and improving ischemic ECG than the control from seven studies by Meta-analysis.Conclusion It’s manifested that cinepazide maleate injection has certain curative effect on unstable angina pectoris and lower occurrence of adverse reaction by Meta-analysis,which needs further verifying by randomized control trial with strict design and large sample.