| 影响肝移植术后新发糖尿病逆转的相关因素 |
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| 引用本文： | 傅斌生,张彤,安玉玲,李华,易述红,汪根树,许赤,杨扬,蔡常洁,陆敏强,陈规划. 影响肝移植术后新发糖尿病逆转的相关因素[J]. 中华器官移植杂志, 2009, 32(7): 221-223. DOI: 10.3760/cma.j.issn.0254-1785.2011.04.008 |
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| 作者姓名： | 傅斌生 张彤 安玉玲 李华 易述红 汪根树 许赤 杨扬 蔡常洁 陆敏强 陈规划 |
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| 作者单位： | 中山大学附属第三医院肝移植中心,中山大学器官移植研究所,广东省器官移植研究中心,广州,510630; |
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| 基金项目： | 国家重点基础研究发展计划项目(973分课题)十一五科技攻关项目广东省科技计划项目重大专项教育部新教师基金 |
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| 摘 要： | Objective To study the related factors associated with the reversal of posttransplant diabetes mellitus (PTDM) following liver transplantation. Methods The clinical data of 62patients with PTDM in 232 patients receiving liver transplantation (26. 7 %) were retrospectively analyzed and the patients were divided into two groups: patients with transient PTDM (34 cases) and those with persistent PTDM (28 cases). Pre-operative and post-operative variables, including sex,age, body mass index, family history of diabetes, hepatitis B virus infection, pretransplantation fasting plasma glucose, the immunosuppressant regime, FK506 concentration and duration of steroid usage, were analyzed retrospectively. Results The variables, including sex, age, body mass index,family history of diabetes, hepatitis B virus infection, pretransplantation fasting plasma glucose,FK506 concentration at month 1, 3 and 6 after operation, rate of cyclosporine usage and duration of steroid usage had no significant difference between the two groups (P＞0. 05). Compared with the persistent PTDM patients, the transient PTDM patients were characterized by younger age at the time of transplantation (54 ± 8 vs. 42 ± 6 years, P＜0. 05), longer time before the development of PTDM (18 ± 23 vs. 35 ± 42 days, P＜0. 05), and higher rate of mycophenolate mofetil or sirolimus usage (0vs. 8. 9 %, P＜0. 05). Based on a multivariate analysis, age at the time of transplantation was determined as the single independent predictive factor associated with reversal of PTDM following liver transplantation (odds ratio: 1. 312, 95 % confidence interval: 1. 005 - 1. 743). Conclusion Age at the time of transplantation, duration before the development of PTDM and rate of mycophenolate mofetil or sirolimus usage are associated with reversal of PTDM following liver transplantation. Among these factors, age at the time of transplantation is only the single independent predictive factor.
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| 关 键 词： | 肝移植 糖尿病 逆转 危险因素 |
Related factors associated with reversal of new-onset diabetes mellitus following liver transplantation |
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| FU Bin-sheng,ZHANG Tong,AN Yu-ling,LI Hua,YI Shu-hong,WANG Gen-shu,XU Chi,YANG Yang,CAI Chang-jie,LU Min-qiang,CHEN Gui-hua. Related factors associated with reversal of new-onset diabetes mellitus following liver transplantation[J]. Chinese Journal of Organ Transplantation, 2009, 32(7): 221-223. DOI: 10.3760/cma.j.issn.0254-1785.2011.04.008 |
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| Authors: | FU Bin-sheng ZHANG Tong AN Yu-ling LI Hua YI Shu-hong WANG Gen-shu XU Chi YANG Yang CAI Chang-jie LU Min-qiang CHEN Gui-hua |
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| Abstract: | |
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| Keywords: | Liver transplantationDiabetes mellitusReversibilityRisk factors |
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