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迷走神经刺激术治疗顽固性癫痫初步探讨
引用本文:孟凡刚,张建国,马延山,梁树立,张凯,杨岸超,桑林. 迷走神经刺激术治疗顽固性癫痫初步探讨[J]. 中华神经外科杂志, 2009, 26(7): 497-499. DOI: 10.3760/cma.j.issn.1001-2346.2010.06.006
作者姓名:孟凡刚  张建国  马延山  梁树立  张凯  杨岸超  桑林
作者单位:首都医科大学北京市神经外科研究所,100050;首都医科大学附属北京天坛医院神经外科;北京丰台医院神经外科;解放军总医院第一附属医院神经外科;
摘    要:
Objective To investigate the effectiveness of vagus nerve stimulation (VNS) therapy in intractable epilepsy. Methods VNS were performed in twenty - one patients. The generator was turned on 2 weeks after operation. Stimulation parameters were adjusted gradually. The output currents adjusted from 0.25 mA, and less than 3.0 mA. Stimulative time was 30 s ON and 5 min OFF, the frequency was from 20to 30 Hz, and the pulse width was from 250 μs to 1000 μs. The patients were followed up so as to analysis the effectiveness. Results After4 - 16 months of intermittent stimulation of the vagus nerve, grade Ⅰ in 3 patients, grade Ⅱ in 7 patients, grade Ⅲ in 9 patients and grade Ⅴ in 2 patients. Among them, seizure frequency was reduced over 50% occurred in 10 patients. Conclusion VNS can reduce seizure frequency,improve the quality of life in patients with intractable epilepsy, and it is a minimal invasive surgery with few side effects.

关 键 词:癫痫   迷走神经刺激术   预后   

Investigation of vagus nerve stimulation for treatment of intractable epilepsy
MENG Fan-gang,ZHANG Jian-guo,MA Yan-shan,LIANG Shu-li,ZHANG Kai,YANG An-chao,SANG Lin. Investigation of vagus nerve stimulation for treatment of intractable epilepsy[J]. Chinese Journal of Neurosurgery, 2009, 26(7): 497-499. DOI: 10.3760/cma.j.issn.1001-2346.2010.06.006
Authors:MENG Fan-gang  ZHANG Jian-guo  MA Yan-shan  LIANG Shu-li  ZHANG Kai  YANG An-chao  SANG Lin
Abstract:
Keywords:EpilepsyVagus nerve stimulationPrognosis
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