Indolent nonseminomatous germ cell tumor of testis. Prolonged survival of patient with persistent metastatic disease |
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| Authors: | T M Baker A H Chan F H Stutz |
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| Affiliation: | 1. Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran;2. Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Science, Mashhad, Iran;3. Department of Hematology Oncology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran;4. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, UK;5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;7. School of Medicine, The University of Western Australia, Perth, Australia;8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia;2. Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada;3. Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada;4. Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada;5. British Columbia Cancer Agency, Vancouver, British Columbia, Canada |
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| Abstract: | ![]()
The complete response rate of disseminated nonseminomatous germ cell tumors (NSGCT) of the testes with current aggressive chemotherapy and surgical resection of residual disease is between 70 and 80 per cent. Those patients who do not attain complete response tend to have short survivals. A case is presented of a forty-one-year-old white man who has had nearly continuous evidence of metastatic embryonal carcinoma for more than eleven years. Although NSGCTs are characterized by rapid proliferation, early metastasis, high response rate to chemotherapy, and rapid death if uncontrolled, this case demonstrates an indolent form of disease with poor response to chemotherapy and yet prolonged survival in spite of uncontrolled disease. This is the first reported case of indolent metastatic germ cell neoplasm with survival of more than ten years. |
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