| 萘普生钠缓释骨架片的制备及药动学研究 |
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| 引用本文： | 韩丽妹,姬静,方晓玲,崔强. 萘普生钠缓释骨架片的制备及药动学研究[J]. 复旦学报(医学版), 2009, 36(5): 514-518. DOI: |
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| 作者姓名： | 韩丽妹 姬静 方晓玲 崔强 |
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| 作者单位： | 复旦大学药学院药剂学教研室,上海,200032;陶氏化学中国投资有限公司,上海,200021;上海卡乐康包衣技术有限公司,上海,201108 |
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| 基金项目： | 科技型中小企业技术创新基金项目 |
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| 摘 要： | 目的 进行以羟丙基甲基纤维素（hydroxypropylmethycelluose,HPMC）为骨架材料的日服一次的萘普生钠缓释片的研究。方法 考察并比较自制与参比萘普生钠缓释骨架片在pH1.2盐酸液+0.05%吐温80、pH5.0磷酸盐缓冲液+0.05%吐温80、pH6.8磷酸盐缓冲液、pH7.4磷酸盐缓冲液及pH梯度介质中的释放行为。观察骨架材料HPMC的黏度和用量与制剂在pH梯度释放介质中释药速率间的关系,并考察制剂在家兔体内的药动学。结果 体外释放实验表明自制制剂缓释效果良好,体外释药行为符合Higuchi方程,自制制剂和参比制剂的体外释放行为相似度高,在各种释放介质中f2均远大于50。家兔药动学试验结果表明,自制制剂和参比制剂的各药动学参数均无显著性差异（P>0.05）。结论 自制萘普生钠缓释骨架片具有良好的体内外缓释效果。
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| 关 键 词： | 萘普生钠 缓释骨架片 羟丙基甲基纤维素 生物利用度 |
| 收稿时间： | 2008-09-23 |
Preparation and phamacokinetics of sustained-release dosage form of naproxen sodium |
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| HAN Li-mei,JI Jing,FANG Xiao-ling,CUI Qiang. Preparation and phamacokinetics of sustained-release dosage form of naproxen sodium[J]. Fudan University Journal of Medical Sciences, 2009, 36(5): 514-518. DOI: |
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| Authors: | HAN Li-mei JI Jing FANG Xiao-ling CUI Qiang |
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| Affiliation: | Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China; Dow Chemical Company, Shanghai 200233, China; Shanghai Colorcon Coating Technology Ltd., Shanghai 201108, China |
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| Abstract: | Objective To prepare the 24 h sustained-release tablet of naproxen sodium with hydroxypropylmethycelluose(HPMC) as matrix material. Methods The in vitro release behaviors of test and reference naproxen sodium tablets in various release media,such as pH1.2 HCl +0.05% Tween 80,pH5.0 phosphate buffer +0.05% Tween 80,pH6.8 phosphate buffer,pH7.4 phosphate buffer and pH gradient medium,were compared.The correlation between viscosity and amount of HPMC and drug release rate in pH gradient medium was studied.The p... |
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| Keywords: | naproxen sodium sustained-release tablets hydroxypropyl methylcellulose bioavailability |
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