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Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity
Authors:Barbara Costa  Eleonora Da Pozzo  Beatrice Chelli  Nicola Simola  Micaela Morelli  Michele Luisi  Marco Maccheroni  Sabrina Taliani  Francesca Simorini  Federico Da Settimo  Claudia Martini
Affiliation:1. Department of Human Morphology and Applied Biology, University of Pisa, via Volta, 4-56126 Pisa, Italy;2. Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, via Bonanno, 6-56126 Pisa, Italy;3. Institute for Nanostructured Materials – National Research Council of Italy, Via P. Gobetti 101, I-40129 Bologna, Italy;4. Department of Toxicology, University of Cagliari, via Ospedale, 72-09124 Cagliari, Italy;5. Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, via Ospedale, 72-09124 Cagliari, Italy;6. Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, via Roma 67-56100 Pisa, Italy;g Laboratory of Endocrinology, S. Chiara Hospital, University of Pisa, via Roma 67-56100 Pisa, Italy;h Department of Pharmaceutical Science, University of Pisa, via Bonanno, 6-56126 Pisa, Italy
Abstract:
Keywords:Translocator protein   Neurosteroids   MPIGA   GABAA receptor   Synaptoneurosomes   Anxiolytic effects
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