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Effect of isoproterenol upon serotonin N-acetyltransferase (SNAT) activity and melatonin production in the chick pineal gland |
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| Authors: | Claramae H. Miller M.L. Lakin M.L. Stott N. Wenger L.S. Rosenblatt W.D. Winters |
| Affiliation: | 1. Departments of Pathology, University of California, Davis, CA 95616 U.S.A.;2. Departments of Internal Medicine, University of California, Davis, CA 95616 U.S.A.;3. Departments of Pharmacology, School of Medicine, University of California, Davis, CA 95616 U.S.A.;4. Laboratory for Energy Related Health Research, School of Veterinary Medicine, University of California, Davis, CA 95616 U.S.A. |
| Abstract: | The administration of isoproterenol to chicks (5 days after hatching) resulted in a modest increase in pineal serotonin N-acetyltransferase (SNAT) activity and a decrease in pineal melatonin levels. The changes observed following isoproterenol administration did not occur consistently in a dose-related or time-course related manner, nor were these changes of the magnitude seen in endogenous nocturnal melatonin levels. Therefore, interpretation of the physiological significance of the isoproterenol-induced changes in melatonin and SNAT must be carefully evaluated. |
| Keywords: | pineal circadian melatonin chicks isoproterenol radioimmunoassay |
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