阿托伐他汀在高血压合并颈动脉粥样硬化患者中的作用

目的:探讨阿托伐他汀在高血压病患者合并颈动脉粥样硬化患者中的作用。方法:182例高血压病2级伴颈动脉粥样硬化患者随机分为阿托伐他汀组(91例)和对照组(91例),两组均给予高血压病标准治疗,他汀组在标准治疗上加用阿托伐他汀片,分别观察不同治疗时期脑梗塞的发生率。结果:阿托伐他汀治疗组3个月内脑梗塞发生率与对照组比较无显著差异(1.1%∶2.2%,P0.05),2年内脑梗塞发生率明显低于对照组(2.2%∶9.9%,P0.05)。结论:阿托伐他汀具有稳定动脉粥样斑块,改善血管内皮功能状态的作用,其在改善脑梗塞患者长期预后方面具有积极作用。

Therapeutic role of atorvastatin in hypertensive patients with carotid atherosclerosis

Objective： To investigating the therapeutic role of atorvastatin in hypertensive patients with carotid athero- sclerosis. Methods： A total of 182 patients with hypertension of stage 2 and carotid atherosclerosis were average ran- domly divided into two groups： atorvastatin group （n=91） and routine therapy control group （control group, n=91） and were all given standard treatment of hypertension, but atorvastatin group was given atorvastatin tablets also. The incidence of brain infarction during different period of treatment was observed. Results： Incidence of brain infarction in 3 months of atorvastatin treatment group showed no significant difference with that of control group （1.1% vs. 2.2%, P〈0. 05）, but the incidence in two years was significantly lower than that of control group （2.20% vs. 9.9%, P〈0.05）. Conclusion： Atorvastatin can improve the stabilization of atherosclerotic plaque and endothelial function. So it plays an active role in improving the long term prognosis in patients with brain infarction.