对冠状动脉慢血流现象并高尿酸水平患者干预作用的意义研究

目的：探讨对冠状动脉慢血流现象心绞痛并高尿酸水平患者干预作用的影响。方法：将40例冠状动脉慢血流现象患者随机分为治疗组及对照组。对照组在饮食调节、戒烟、戒酒的基础上，根据需要常规予以阿司匹林、氯吡格雷、血管紧张素转化酶抑制剂、β-受体阻滞剂、硝酸酯类药等治疗，治疗组在对照组基础上给予苯溴马隆50mg／d治疗半年。检测两组治疗前后血浆尿酸水平，并比较两组的总有效率及再住院率。结果：两组治疗前后尿酸水平差异有统计学意义（P〈0．05），但治疗组较对照组改善更显著（P〈0．05）。治疗组显效14例，有效5例，无效1例，总有效率95．0％；对照组显效8例，有效5例，无效7例，总有效率65．0％；治疗前后两组比较，差异有统计学意义（P〈0．05）。对照组因心绞痛再次人院者6例（30．0％），治疗组1例（5．0％），两组比较，差异有统计学意义（P〈0．05）。结论：降低血清尿酸水平对于控制冠状动脉慢血流现象患者的临床症状是有效的。

Significances of Intervention Effect on Hyperuricemia in Angina Pectoris Patients with Coronary Slow Flow Phenomenon

Objective： To investigate the significances of intervention effect on high plasma level of uricemia in angina pectoris patients with coronary slow flow phenomenon. Methods： 40 cases of coronary slow flow phenomenon were randomly divided into treatment group and control group. The control group, on the basis of diet, smoking, and drinking, was given aspirin, clopidogrel, routine to angiotensin converting enzyme inhibitors, beta-blockers, nitrates drugs, and the treatment group was given benzyl bromide Malone 50 mg/d treatment for half a year. To detect plasma uric acid levels of the two groups, and compare the total efficiency and the rate of rehospitalization between the two groups. Results： The level of plasma uricemia of the two groups decreased markedly（P〈0.05）. A significant decrease of plasma uricemia level was observed after taking benzobromarone for 6 months（P〈0.05）. In the treatment group, 14 cases got marked effectiveness, 5 cases got effectiveness, 1 case got failure, and the total effective rate was 95.0%. In the control group, 8 cases got marked effectiveness, 5 cases got effectiveness, 7case got failure, and the total effective rate was 65.0%. In the treatment group, there were one case of rehospitalization, and the total rehospitalizatiou rate was 5.0%. In the control group, there were 6 cases of rehospitalization, and the total rehospitalization rate was 30.0%. A significant increased of the rehospitalization rate was observed in the control group. Conclusion： Intervention effect can effectively decrease the level of plasma uricemia and improve the prognosis of the patients with coronary slow flow phenomenon.