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| 比索洛尔治疗慢性充血性心力衰竭对外周血中利钾尿肽、肾素活性和心房钠尿肽水平的影响 | |
| 引用本文： | 唐发宽,华宁,钮炜西,肖军,陆宏,唐雪正,齐帜,曾强. 比索洛尔治疗慢性充血性心力衰竭对外周血中利钾尿肽、肾素活性和心房钠尿肽水平的影响[J]. 医学争鸣, 2009, 30(2) |
| 作者姓名： | 唐发宽 华宁 钮炜西 肖军 陆宏 唐雪正 齐帜 曾强 |
| 作者单位： | 唐发宽,华宁,钮炜西,肖军,陆宏,唐雪正,齐帜,TANG Fa-Kuan,HUA Ning,NIU Wei-Xi,XIAO Jun,LU Hong,TANG Xue-Zheng,QI Zhi(解放军总医院附属第二医院心内科,北京,100091);曾强,ZENG Qiang(解放军总医院南楼心血管二科,北京,100853) |
| 摘 要： | 目的:探讨B受体阻滞剂比索洛尔治疗充血性心力衰竭(CHF)时对外周血中利钾尿肽(KP)、肾素活性(PRA)和心房钠尿肽(ANP)水平的影响.方法:120例充血性心力衰竭患者随机分为常规治疗组(血管紧张素转换酶抑制剂+利尿剂+地高辛)和比索洛尔组(常规治疗药物+比索洛尔),随访12 wk,采用放射免疫分析方法测定两组治疗前后和60例健康体检者(正常对照组)外周血浆中KP,PRA和ANP水平.同时使用核素心室显像测定心衰患者左心室射血分数(LVEF).结果:CHF患者的血浆KP,PRA和ANP水平较正常对照组显著升高,其中,KP和ANP水平在比索洛尔治疗前与LVEF显著负相关,但PRA水平与LVEF无关,随着病情的好转其水平逐渐降低,且不同的心功能分级组之间有显著差异(P<0.05).在比索洛尔治疗后,比索洛尔组外周血浆中KP,PRA和ANP水平较常规治疗组明显下降.结论:血浆KP与ANP含量的改变水平在CHF病理生理中起着一定的作用,且在B受体阻滞剂治疗后仍可用于指导CHF患者的治疗.B受体阻滞剂能抑制CHF患者神经内分泌的过度激活. |
| 关 键 词： | 心力衰竭,充血性 利钾尿肽 心钠系 肾素 |
Effects of bisoprolol on kaliuretic peptide,plasma renin activity and atrial natriuretic peptide in patients with chronic congestive heart failure |
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| TANG Fa-Kuan,HUA Ning,NIU Wei-Xi,XIAO Jun,LU Hong,TANG Xue-Zheng,QI Zhi,ZENG Qiang. Effects of bisoprolol on kaliuretic peptide,plasma renin activity and atrial natriuretic peptide in patients with chronic congestive heart failure[J]. Negative, 2009, 30(2) | |
| Authors: | TANG Fa-Kuan HUA Ning NIU Wei-Xi XIAO Jun LU Hong TANG Xue-Zheng QI Zhi ZENG Qiang |
| Affiliation: | TANG Fa-Kuan1,HUA Ning1,NIU Wei-Xi1,XIAO Jun1,LU Hong1,TANG Xue-Zheng1,QI Zhi1,ZENG Qiang21Department of Cardiovasology,Second Affiliated Hospital,Chinese PLA General Hospital,Beijing 100091,2Second Department of Geriatric Cardiovasology,Beijing 100853,China |
| Abstract: | AIM: To investigate the levels of kaliuretic peptide(KP),plasma renin activity(PRA) and atrial natriuretic peptide(ANP) in patients with chronic congestive heart failure(CHF) and to evaluate the beneficial effects of beta-blockers on the variables mentioned above.METHODS: One hundred and twenty patients with CHF were divided into two subgroups randomly.Routine group was treated with routine drugs(ACE inhibitors,diuretics and digoxin,n=60),while bisoprolol group was given beta-blocker(bisoprolol,n=60) additi... |
| Keywords: | heart failure congestive kaliuretic peptide atrial natriuretic factor renin |
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