| 脑源性神经营养因子在创伤后鼠脑中的表达 |
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| 引用本文： | 贾丛林 田碧野 等. 脑源性神经营养因子在创伤后鼠脑中的表达[J]. 齐齐哈尔医学院学报, 2001, 22(7): 726-727 |
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| 作者姓名： | 贾丛林 田碧野 等 |
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| 作者单位： | [1]齐齐哈尔医学院第一附属医院神经外科161041 [2]黑龙江省富拉尔基发电总厂医院外科 |
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| 摘 要： | 目的 通过对鼠脑机械创伤后测定脑皮层及海马CA2区脑源性神经营养因子（Brain-derived neurotrophic factor,BDNF)的含量变化说明BDNF是否对脑创伤神经元有保护作用。方法 建立鼠脑创伤模型，取鼠脑用免疫组化方法测定创伤后不同时间BDNF表达含量变化。与设立的假手术对照组相比较，并进行组间比较。结果 创伤后鼠脑与假手术组比较，创伤组BDNF明显表达，时间为伤后12h，在2h为表达高峰期（P＜0．01）。结论 BDNF对脑创伤后神经元有保护作用。
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| 关 键 词： | 脑源性神经营养因子 脑创伤 表达 |
Expression of Brain-derived Neurotrophic Factor (BDNF) in Injured Rat Brain |
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| Jia Conglin,et al.. Expression of Brain-derived Neurotrophic Factor (BDNF) in Injured Rat Brain[J]. Journal of Qiqihar Medical College, 2001, 22(7): 726-727 |
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| Authors: | Jia Conglin et al. |
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| Abstract: | Objective To interpret BDNF have protective function to injured neuron through measuring expression of BDNF in cerebral cortex and hippocampus CA2 of the mechanically injured rat cerebrum.Methods To establish the model of injured rat ceredrum and measure expression of BDNF in different time with the method of immunihistochemitstry in injured rat cerebrum,to compare with the false operative group and between both two groups.Results Expression of BDNF exist in the injured rat brain,namely,expression of BDNF obveriously increase than the false operative group.From the comparing between two groups,increasing expression time is in 1 hour to 12hour after injury,the peak of expressive BDNF is in 2 hour (P<001).Conclusions BDNF can protect neuron avoid to be injured in the damaged rat brain. |
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| Keywords: | Brain-derived neurotrophic factor Rat Injured brain |
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