膀胱移行细胞癌组织中MMP-2、MMP-9和CD147表达及相互关系

目的：探讨膀胱移行细胞癌组织基质金属蛋白酶-2、9（MMP-2、MMP-9）和细胞外基质金属蛋白酶诱导因子（CD147）的表达和相互关系。方法：采用免疫组织化学sP法检测48例膀胱移行细胞癌组织及16例正常膀胱黏膜组织MMP-2、MMP-9和CD147的表达情况，比较不同临床、病理特征膀胱移行细胞癌患者CD147和MMP-2、MMP-9的表达及其相关性。结果：膀胱移行细胞癌组织中MMP-2、MMP-9和CD147的阳性表达率分别100％、95．8％、95．8％，均明显高于正常膀胱黏膜组织（P均〈0．05）；其阳性表达与肿瘤的病理分级、临床分期呈正相关（P〈0．05），与临床预后无显著相关（P〉0．05）；膀胱移行细胞癌组织CD147与MMP-2、MMP-9多同时表达，呈现出显著正相关，相关系数分别为0．784、0．853（P〈0．001）。结论：MMP-2、MMP-9、CD147在膀胱移行细胞癌发展中可能起着重要的作用。MMP-2和MMP-9的分泌增加可能与CD147的诱导促进作用有关系。

Expression of MMP-2, MMP-9 and CD147 and their relationships in bladder transitional cell carcinoma

Objective:To investigate the expression of MMP-2,MMP-9 and CD147 in bladder transitional cell carcinoma and their relationships. Methods:The expression of MMP-2,MMP-9 and CD147,in cancer tissue of 48 patients with bladder transitional cell carcinoma and in normal tissue of 16 controls were detected by immunohistochemistry,and compared,and their relationships were evaluated. Results:The positive rates of MMP-2,MMP-9 and CD147 expression in bladder transitional cell carcinoma (100%,95.8% and 93.8% respectively) were significantly higher than those in controls (P<0.05). The positive expression was significant correlated to the pathological grade and clinical stages (P<0.05),but negatively related to clinical prognosis (P>0.05). Simultaneous expression of MMP-2,MMP-9 and CD147 were frequently showed in bladder transitional cell carcinoma tissue and had a notable correlation,correlation coefficients were 0.784 and 0.853 (P<0.001),respectively. Conclusion:MMP-2,MMP-9 and CD147 may play important roles in the development of bladder transitional cell carcinoma. The increased secretion of MMP-2,and MMP-9 may be related to the inducement of CD147.