不同代谢综合征诊断标准下新疆维吾尔族糖代谢异常人群血脂谱的分析

目的采用三种不同代谢综合征建议诊断标准，观察新疆糖维吾尔族代谢异常人群代谢综合征的患病率、检查率差异以及代谢综合征组分数目累积对血脂谱的影响。方法采用分层整群随机抽样获得666例维吾尔族糖代谢异常人群，采用2001年美国国家胆固醇教育计划第三次报告（NcEP—ATPIII）、2004年中华医学会糖尿病学分会（CDS）和2005年国际糖尿病联盟（IDF）的代谢综合征建议诊断标准分析其代谢综合征组分和血脂谱。结果ATPIII（2001）、CDS（2004）、IDF（2005）诊断标准下代谢综合征的患病率（标化患病率）分别为21．92％（14．67％），23．72％（15．88％），57．5l％（38．48％）；IDF（2005）诊断优于其他两种标准（P〈0．05）。ATPⅢ（2001）标准下，随着代谢综合征组分数目的增加，高密度脂蛋白胆固醇水平下降，低密度脂蛋白胆固醇水平升高；CDS（2004）标准下，各项血脂变化差异无统计学意义（P〉0．05）；IDF（2005）标准下，甘油三酯水平显著升高。结论三种诊断标准下，维吾尔族糖代谢异常人群中均有较高的代谢综合征患病率；代谢异常均伴有血脂异常；表现为容易导致心血管疾病的血脂谱，即甘油三酯水平升高、高密度脂蛋白胆固醇水平降低和低密度脂蛋白胆固醇水平升高。

Analysis of blood lipid profile of the Uyghur people with abnormal glucose metabolism in Xinjiang province by different diagnostic criteria for metabolic syndrome

Objective To study the prevalence of metabolic syndrome （MS） within the Uyghur people with abnormal glucose metabolism in Xinjiang province according to three different diagnostic criteria and effects of accumulation of MS components on blood lipid profile. Methods Components of MS and blood lipid profile were observed with 666 Uyghur people with abnormal glucose metabolism after cluster randomized sampling method for selecting in Xinjiang province, and analyzed with the recommended diag- nostic criteria by the National Cholesterol Education Program-Aduh treatment Panel m （NCEP-ATP m, 2001 ）, the Chinese Diabetes Society under Chinese Medical Association （CDS,2004） and the International Diabetes Federation （ IDF, 2005 ）. Results Prevalence of MS was 21.92% （ 14. 67% ） , 23.72% （ 15.88% ）, 57.51% （38.48%） with the criteria by NCEP-ATPIII, CDS, and IDF,respectively. IDF was the best among three criteria. The most combination was the abnormal glucose metabolism, dyslipidemia and obesity. In the ATPIII （2001）, with the increase of number of components of metabolic syndrome, high- density lipoprotein cholesterol （HDL-C） drop, low density lipoprotein cholesterol （LDL-C） increased; there was not significant difference in the CDS. Conclusions The incidence of MS was high in the Uyghur people with abnormal glucose metabolism in Xinjiang province. Most of them complicated with dyslipidemia. One of common components of MS included the elevated triglycerides,decreased HDL-C, and increased sizeof LDL-C particles, which could easily cause cardiovascular disease.