| HLA-DRB1*0301等位基因与Graves病的关系 |
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| 引用本文： | 吴美芬,武革,吴雪梅,苏敏,蔡康荣,吴平.HLA-DRB1*0301等位基因与Graves病的关系[J].国际免疫学杂志,2008,31(2). |
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| 作者姓名： | 吴美芬 武革 吴雪梅 苏敏 蔡康荣 吴平 |
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| 作者单位： | 广东医学院附属医院内分泌科,湛江,524001 |
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| 摘 要： | 目的 探讨HLA-DRB1*0301等位基因在粤西湛江沿海地区Graves病(GD)发病中的作用.方法 选取65例初诊GD病人和正常对照50例并采用多聚酶链反应-序列特异性引物(PCR-SSP)技术检测HLA-DRB1*0301等位基因的表达频率.结果 初诊GD病人HLA-DRBl*0301等位基因的表达频率显著高于正常对照组(P＜0.005).结论 HLA-DRB1*0301等位基因可能是粤西湛江地区GD的易感基因.
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| 关 键 词： | Graves病 遗传易感 HIJA-DRB1*0301等位基因 |
The relation between HLA-DRB1*0301 allele and Graves disease |
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| WU Mei-fen,WU Ge,WU Xue-mei,SU Min,CAI Kang-rong,WU Ping.The relation between HLA-DRB1*0301 allele and Graves disease[J].International Journal of Immunology,2008,31(2). |
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| Authors: | WU Mei-fen WU Ge WU Xue-mei SU Min CAI Kang-rong WU Ping |
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| Abstract: | Objective To study the relation between HIA-DRB1*0301 allele and Graves disease(GD)in Zhanjiang coastal areas.Methods The HLA.DRB1*0301 allele was examined by polymerase chain reaction with sequence specific primers(PCR-SSP)in 65 patients with preliminary Graves disease and 50 normal subjects.Results The frequency of HLA-DRB1*0301 allele was significantly higher in preliminary GD group than that in the control group(P＜0.005).Conclusion The HLA-DRB1*0301 allele may be the predisposing gene for GD in Zhanjiang coastal areas. |
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| Keywords: | Graves disease Heredity HLA-DRB1*0301 allele |
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