银杏总黄酮胃肠吸收动力学研究

目的：研究银杏提取物中总黄酮在大鼠胃肠道中的吸收动力学特征。方法：采用大鼠在体胃肠循环装置,以银杏总黄酮为考察指标,采用UV法和HPLC法检测总黄酮和酚红在大鼠在体胃、肠循环的含量。结果：大鼠在体肠回流吸收实验3h后,供试品在小肠上部的吸收百分率和吸收速率实验结果显示,药物吸收较好的部位在中上部,但与全肠比亦较差。吸收百分率和吸收速率按照十二指肠、空肠、结肠、回肠依次降低;在总黄酮浓度1mg/mL、2mg/mL、3mg/mL范围内药物的吸收量与浓度有良好的线性关系,没有吸收饱和现象发生。而吸收速度常数基本不变,表明银杏总黄酮的吸收是被动扩散。

Gastroenteric Absorptive Kinetic Study on Ginkgo Biloba Flavonoids

Objective：Studies on Absorption Kinetics of ginkgo biloba extract（total ginkgo flavones）in Rats.Methods：Determination of total ginkgo flavones and phenol red in rats by HPLC and UV.Results：Rats in the back-intestinal absorption experiments after 3 hours,the test for chemicals in the upper part of the small intestine to absorb the percentage rate of absorption and experimental results show that the absorption of drugs in a better position in the upper part,but also less than the entire intestine.And the percentage of the absorption rate of absorption in accordance with the duodenum,jejunum,colon,followed by lower ileum;in the total concentration of flavonoids 1mg/mL,2mg/mL,3mg/mL within the scope of drug absorption and concentration of a good linear relationship,there is no Saturated absorption phenomenon.The absorption rate constant is essentially the same,showed that total flavonoids of Ginkgo biloba is a passive absorption of proliferation.