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肺结核患者治疗前后血清GM-CSF和hs-CRP水平检测的临床意义
引用本文:李清,廖郎,谢晋,康熙雄.肺结核患者治疗前后血清GM-CSF和hs-CRP水平检测的临床意义[J].标记免疫分析与临床,2008,15(3):145-146.
作者姓名:李清  廖郎  谢晋  康熙雄
作者单位:1. 新疆维吾尔族自治区中医院检验科,新疆,乌鲁木齐,830000
2. 新疆哈密红星医院,新疆,哈密,839000
3. 新疆乌鲁木齐市疾病控制中心,新疆,乌鲁木齐,830000
4. 首都医科大学北京天坛医院,北京市,100050
摘    要:探讨了肺结核患者治疗前后血清粒细胞巨噬细胞集落刺激因子(GM-CSF)和hs-CRP水平的变化及其意义.应用放免法和免疫比浊法对40例肺结核患者进行了血清GM-CSF和hs-CRP水平测定,并与35名正常人作对照.在治疗前肺结核患者血清GM-CSF和hs-CRP水平均显著高于正常人组(P<0.01),经3个月治疗后血清GM-CSF和hs-CRP水平与正常人比较无显著性差异(P>0.05).患者治疗前后的血清GM-CSF和hs-CRP水平具有显著性差异(P<0.01).检测肺结核患者血清中GM-CSF和hs-CRP水平的变化与患者的病情和预后密切相关,有重要的临床价值.

关 键 词:肺结核  粒细胞巨噬细胞集落刺激因子  超敏C反应蛋白
文章编号:1006-1703(2008)03-0145-02
修稿时间:2008年2月22日

Clinical Significance of Determination of Serum GM-CSF and hs-CRP levels After Treatment in Patients with Tuberculosis
LI Qing,LIAO Lang,XIE Jin,et al..Clinical Significance of Determination of Serum GM-CSF and hs-CRP levels After Treatment in Patients with Tuberculosis[J].Labeled Immunoassays and Clinical Medicine,2008,15(3):145-146.
Authors:LI Qing  LIAO Lang  XIE Jin  
Abstract:To explore the changes of serum GM-CSF and hs-CRP levels in patients with tuberculosis and their clinical significance,the serum GM-CSF and hs-CRP levels in 40 patients with tuberculosis before and after treatment as well as in 35 health controls were determined by RIA and immune-turbidimetry method respectively.The results showed that the serum GM-CSF and hs-CRP levels in patients before treatment were significantly higher than those in controls(P<0.01).The serum GM-CSF and hs-CRP levels in patients after 3 months treatment had no significant difference from those in controls(P>0.05).The serum GM-CSF and hs-CRP levels in patients before the treatment were significantly higher than those after treatment(P<0.01).The detection the changes of serum GM-CSF and hs-CRP levels have clinical significance in the treatment and predict prognosis of tuberculosis.
Keywords:Tuberculosis  Granulocyte-macrophage colony stimulating factor(GM-CSF)  High sensitive C reactive protein(hs-CRP)
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