奥硝唑阴道泡腾片治疗细菌性阴道病的临床疗效与安全性研究

目的:观察奥硝唑阴道泡腾片治疗细菌性阴道病的临床疗效与安全性。方法:采用盲法、随机平行对照的方法,将132例确诊患者分成试验组(n=67)和对照组(n=65)。试验组使用奥硝唑阴道泡腾片,对照组使用甲硝唑阴道泡腾片,治疗7d。治疗后3～5d、28～35d观察疗效。结果:试验组治疗结束后3～5d的临床综合疗效评价痊愈率为88.52,有效率为95.08;28～35d,临床综合疗效评价痊愈率为93.44,有效率为96.43,对照组分别78.69、91.80、85.25、90.17,不良反应发生率分别为1.5、4.9,以上两组比较差异无统计学意义(P>0.05)。结论:奥硝唑阴道泡腾片治疗细菌性阴道病疗效确切,不良反应发生率低。

Clinical efficacy and safety of ornidazole vaginal effervescent tablets in the treatment of bacterial vaginitis

AIM:To evaluate the clinical efficacy and safety of ornidazole vaginal effervescent tablets in the treatment of bacterial vaginitis.METHODS:A random,double blind and parallel control trial method was adopted.132 patients with bacterial vaginitis were randomly assigned into trial group(67 cases) or control group(65 cases).And patients received ornidazole vaginal effervescent tablets or metronidazole vaginal effervescent tablets once daily for 7 days.Therapeutic effect of two groups were observed in 3-7 days and 28-35 days after treatment.RESULTS:The clinical cure rate,efficacy rate in 3-7 days and 28-35 days after the treatment were 88.52%,95.08%,93.44%,96.43% respectively,while those for control group were 78.69%,91.80%,85.25%,90.17% respectively.Adverse effect occurrence rate of trial group and control group were 1.5% and 4.9% respectively.There were no significant differences between the two groups(P>0.05).CONCLUSION:Ornidazole vaginal effervescent tablets is a safe and effective agent for the treatment of bacterial vaginitis.