| 紫外分光光度法测定西地那非的电离平衡常数 |
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| 引用本文： | 胡湘南,范博. 紫外分光光度法测定西地那非的电离平衡常数[J]. 中国药房, 2006, 17(2): 134-136 |
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| 作者姓名： | 胡湘南 范博 |
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| 作者单位： | 重庆医科大学药学系,重庆市,400016 |
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| 摘 要： | 目的:建立以紫外分光光度法测定西地那非电离平衡常数的方法。方法:将pH值各为2.26、8.56、9.31、9.83、12.38的西地那非甲醇溶液分别于200nm～400nm波长范围内扫描,并在选定的280、287、290、295、297nm波长处测定其吸收度,计算电离平衡常数的负对数(pKa)值。结果:西地那非的pKa值为9.35±0.02。结论:本方法简便、易行。
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| 关 键 词： | 紫外分光光度法 西地那非 电离平衡常数 |
| 文章编号： | 1001-0408(2006)02-0134-03 |
| 收稿时间： | 2005-08-10 |
| 修稿时间： | 2005-11-07 |
Determination of Ionization Equilibrium Constant of Sildenafil by UV Spectrophotometry |
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| HU Xiang nan,FAN Bo. Determination of Ionization Equilibrium Constant of Sildenafil by UV Spectrophotometry[J]. China Pharmacy, 2006, 17(2): 134-136 |
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| Authors: | HU Xiang nan FAN Bo |
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| Abstract: | OBJECTIVE:To establish a method for determination of ionization equilibrium constant of sildenafil using ultraviolet spectrophotometry.METHODS:Methanol solutions of sildenafil with pH values of 2.26,8.56,9.31,9.83 and 12.38 were respectively scanned at the wavelength within the range of 200nm～400nm.The absorbability and pKa value of sildenafil were determined at the selected wavelength of 280,287,290,295 and 297nm respectively.RESULTS:The pKa value of sildenafil was 9.35±0.02.CONCLUSION:The present method is convenient and practicable. |
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| Keywords: | UV Spectrophometry Sildenafil lonization equilibrium constant |
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