子痫前期的预测和预防引发的思考

子痫前期是常见的妊娠期并发症,严重危害母儿健康。多年来业界一直在探索预测子痫前期的方法。除临床病史和体征外,血清学指标和子宫动脉血流频谱也具有一定的价值,但是对于最佳的筛查策略尚无定论。子痫前期预防的研究涉及抗血小板药物、生活方式干预等,目前仍有待于大规模临床研究证实其有效性。我们回顾了子痫前期预测和预防的一些研究进展,将有助于理解对疾病的干预方法从"发现"到"临床小试"再到"临床广泛应用"所需要的严谨和审慎。

Thinking about the prediction and prevention of preeclampsia

Preeclampsia is a serious complication of pregnancy, which is associated with considerable adverse effects on the mothers and the fetus. Numerous researches intended to predict preeclampsia have been performed -- such as many serum markers and uterine artery pulsatility index with Doppler and so on, however the optimal screening modality is still to be explored. Prevention of preeclampsia is also a big challenge. Antiplatelet agents and lifestyle interventions have showed certain protective effects while some new agents are in clinical trial, but these treatments need to be tested in future large -scale randomized studies. In this article, the authors reviewed clinical trials on prediction and prevention of preeelampsia to show new interventions going through ＂clinical discovery＂ to ＂clinical trial＂ and eventually ＂large - scale studies＂ to gather additional information about their safety and efficacy.