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| 表观遗传学在慢性鼻窦炎伴鼻息肉发病机制中的作用 | |
| 引用本文： | 李佳倪,朱冬冬,孟粹达. 表观遗传学在慢性鼻窦炎伴鼻息肉发病机制中的作用[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 84-91. DOI: 10.6040/j.issn.1673-3770.0.2021.562 |
| 作者姓名： | 李佳倪 朱冬冬 孟粹达 |
| 作者单位： | 1.吉林大学中日联谊医院 耳鼻咽喉头颈外科, 吉林 长春 130033;2.吉林省上气道过敏性疾病精准诊疗实验室, 吉林 长春 130033 |
| 基金项目： | 国家自然科学基金项目(81870701,82071016);吉林省自然科学基金项目(20200201411JC,20200201600JC,20200201200JC);吉林省重点实验室建设项目(20190901003JC);吉林省卫生科研人才专项项目(2019scz004,2020scz24);吴阶平医学基金会临床科研专项(320675018380) |
| 摘 要： | 慢性鼻窦炎伴鼻息肉其确切的发病机制尚未完全明确。表观遗传学(Epigenetics)主要指基于非基因序列改变所致基因表达水平的变化，包括DNA甲基化、组蛋白修饰和非编码RNA调控等。就相关基因的表观遗传学修饰及其引起的相应细胞因子和蛋白质等的表达改变在CRS发病机制中的作用作一综述，从全新的角度认识CRS,为明确其发病过程、探究治疗方法提供新的方向。 |
| 关 键 词： | 慢性鼻窦炎 鼻息肉 表观遗传学 甲基化 发病机制 |
The role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps |
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| LI Jiani,ZHU Dongdong,MENG Cuida. The role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 84-91. DOI: 10.6040/j.issn.1673-3770.0.2021.562 | |
| Authors: | LI Jiani ZHU Dongdong MENG Cuida |
| Affiliation: | 1. Department of Otorhinolaryngology & Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China;2. Jilin provincial Key Laboratory of Precise Diagnosis and Treatment of Upper Airway Allergic, Changchun 130033, Jilin, China |
| Abstract: | The pathogenesis of chronic rhinosinusitis(CRS)with nasal polyps has not been fully elucidated. Epigenetics mainly refers to changes in gene expression levels based on non-gene sequence changes, such as DNA methylation, histone modification, and microRNA regulation. In this review, the role of epigenetic modification of CRS-related genes and changes in the expression levels of corresponding cytokines and other related proteins in the pathogenesis of CRS are discussed. The aim of this review is to provide new directions for research on the pathogenesis of CRS and the development of therapeutic methods. |
| Keywords: | Chronic Rhinosinusitis Nasal Polyps Epigenetics Methylation Pathogenesis |
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