汉防己甲素调控肿瘤细胞自噬的研究进展

自噬是一种高度保守的溶酶体介导的细胞进程,对维持细胞内稳态具有重要意义,与多种疾病的发生发展密切相关,在肿瘤细胞中具有双重作用。汉防己甲素是从植物中提取的一种双苄基异喹啉类生物碱,在体内外均显示出广泛的抗肿瘤作用,近年来其调节自噬的活性受到了广泛的关注和研究。综述近10年来汉防己甲素在调控肿瘤细胞自噬中的研究进展,为其抗肿瘤作用提供研究思路。

Tetrandrine regulates autophagy in tumor cells

Autophagy is a highly conserved cellular process mediated by lysosomes, which is important to maintain cell homeostasis. It is closely related to the occurrence and development of many diseases and plays a dual role in tumor.Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the traditional Chinese medicine, exhibits the antitumor activity with multiple bioactivities in vivo and in vitro. Recently, the activity of tetrandrine in regulating autophagy has attracted much attention. This paper reviews the research progress of tetrandrine in the regulation of tumor autophagy in recent 10 years to provide a new way in the use of tetrandrine as an antitumor drug.