| 响应曲面法优化金水六君煎回流提取工艺 |
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| 引用本文： | 于亚云,冯育林,吴欢,夏梦棋,喻文韬,姚闽,张武岗.响应曲面法优化金水六君煎回流提取工艺[J].中国现代中药,2023,25(3):582-589. |
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| 作者姓名： | 于亚云 冯育林 吴欢 夏梦棋 喻文韬 姚闽 张武岗 |
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| 作者单位： | 1.江西中医药大学 中药固体制剂制造技术国家工程研究中心，江西 南昌 330006;2.创新药物与高效节能降耗制药设备国家重点实验室，江西 南昌 330006;3.江西省药品检验检测研究院，江西 南昌 330029 |
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| 基金项目： | 江西省中医药中青年骨干人才培养计划项目（S21-09）；江西中医药大学校级科技创新团队发展计划项目 |
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| 摘 要： | 目的 优选金水六君煎中阿魏酸和橙皮苷回流提取工艺。方法 在单因素试验基础上，以提取时间、液料比、提取次数为影响因素，以阿魏酸和橙皮苷提取率为考察指标，采用响应曲面法优化金水六君煎回流提取工艺。结果 金水六君煎的最佳回流提取工艺为提取1.5 h、液料比12∶1，提取2次。在此工艺条件下，重复3次试验，阿魏酸提取率为60.59%，RSD为0.34%；橙皮苷提取率为59.67%，RSD为2.18%。结论 响应曲面法优化得到的金水六君煎最佳回流提取工艺参数稳定可靠，具有可行性和实用性。
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| 关 键 词： | 经典名方 金水六君煎 响应曲面法 橙皮苷 阿魏酸 |
| 收稿时间： | 2022/8/11 0:00:00 |
Optimization of Reflux Extraction Process of Jinshui Liujun Decoction by Response Surface Methodology |
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| YU Ya-yun,FENG Yu-lin,WU Huan,XIA Meng-qi,YU Wen-tao,YAO Min,ZHANG Wu-gang.Optimization of Reflux Extraction Process of Jinshui Liujun Decoction by Response Surface Methodology[J].Modern Chinese Medicine,2023,25(3):582-589. |
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| Authors: | YU Ya-yun FENG Yu-lin WU Huan XIA Meng-qi YU Wen-tao YAO Min ZHANG Wu-gang |
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| Institution: | 1.National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China;2.State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang 330006, China;3.Jiangxi Institute for Drug Control, Nanchang 330029, China |
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| Abstract: | Objective To optimize the reflux extraction process of ferulic acid and hesperidin from Jinshui Liujun Decoction.Methods On the basis of single factor experiment, the response surface methodology was used to optimize the reflux extraction process of Jinshui Liujun Decoction with reflux time, liquid-to-material ratio, and reflux times as influencing factors, and extraction rate of ferulic acid and hesperidin as the investigation indicator.Results The optimal conditions of the reflux extraction process of Jinshui Liujun Decoction were as follows: reflux time of 1.5 hours, the liquid-to-material ratio of 12:1, and twice reflux.Experiments were repeated three times under the process conditions, and the extraction rates of ferulic acid and hesperidin were 60.59% and 59.67%, with RSDs of 0.34% and 2.18%, respectively.Conclusion The optimized reflux extraction process of Jinshui Liujun Decoction by response surface methodology is accurate and reliable, and it is feasible and practical. |
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