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| Rapid prenatal diagnosis of trisomy 21 by fluorescent quantitative multiplex polymerase chain reaction | |
| 引用本文： | ZHENG Fang ZHOU Xin ZHANG Yuan-zhen SUN Xiao-bo PENG Jian-hong WANG Chun-hong XIONG Chen-ling LI Xia. Rapid prenatal diagnosis of trisomy 21 by fluorescent quantitative multiplex polymerase chain reaction[J]. 中华医学杂志(英文版), 2006, 119(6): 514-517 |
| 作者姓名： | ZHENG Fang ZHOU Xin ZHANG Yuan-zhen SUN Xiao-bo PENG Jian-hong WANG Chun-hong XIONG Chen-ling LI Xia |
| 作者单位： | [1]Gene Diagnosis Center, Zhongnan Hospital of Wuhan University,Wuhan 430071, China [2]Department of Obstetrics and Gynecology, Zhongnan Hospital ofWuhan University, Wuhan 430071, China [3]Department of Public Health, Wuhan University, Wuhan 430071,China |
| 基金项目： | This work was supported by grants from the National Natural Science Foundation of China （No. 30200107） as well as fund fi＇om the Chenguang Plan ofWnhan City （No. 20025001027）. |
| 摘 要： | Trisomy 21, also named Down syndrome was the most frequent autosomal aneuploidy and the most common cause of mental retardation. Fifty percent patients had congenital heart malformation. Every 20 minutes one case of trisomy 21 was born, and the incidence rate was 1 in 600 to 800 newborns in China.1 In two thirds of cases with trisomy 21, there was a spontaneous abortion, so the actual incidence was higher than that obtained postnatally. Trisomy 21 usually occurred due to meiotic non-disjuncti… |
| 关 键 词： | 胎儿 诊断方法 染色体 荧光定量分析 |
| 收稿时间： | 2005-06-10 |
Rapid prenatal diagnosis of trisomy 21 by fluorescent quantitative multiplex polymerase chain reaction |
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| ZHENG;Fang;ZHOU;Xin;ZHANG;Yuan-zhen;SUN;Xiao-bo;PENG;Jian-hong;WANG;Chun-hong;XIONG;Chen-ling;LI;Xia. Rapid prenatal diagnosis of trisomy 21 by fluorescent quantitative multiplex polymerase chain reaction[J]. Chinese medical journal, 2006, 119(6): 514-517 | |
| Authors: | ZHENG Fang ZHOU Xin ZHANG Yuan-zhen SUN Xiao-bo PENG Jian-hong WANG Chun-hong XIONG Chen-ling LI Xia |
| Abstract: | Trisomy 21, also named Down syndrome was the most frequent autosomal aneuploidy and the most common cause of mental retardation. Fifty percent patients had congenital heart malformation. Every 20 minutes one case of trisomy 21 was born, and the incidence rate was 1 in 600 to 800 newborns in China.1 In two thirds of cases with trisomy 21, there was a spontaneous abortion, so the actual incidence was higher than that obtained postnatally. |
| Keywords: | fluorescent quantitative multiplex polymerase chain reaction prenatal diagnosis Down syndrome heterozygosity |
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