新疆哈萨克族健康人群肾功能与中心动脉反射波增强指数和颈动脉内膜中层厚度的相关性分析

目的：探讨新疆哈萨克族健康人群的肾功能与中心动脉反射波增强指数（AIx）和颈动脉内膜中层厚度（CIMT）的关系。方法从新疆塔城地区筛选临床健康居民546例，检测血压、血肌酐、血脂等指标，用中国人校正的 MDRD公式计算肾小球滤过率（GFR），用PWA仪测定中心动脉压，彩色多普勒检测颈动脉内膜中层厚度，运用多元线性回归分析多种因素对 GFR的影响，观察肾功能的改变与中心动脉反射波增强指数和颈动脉内膜中层厚度的关系。结果随着年龄的增长，肾功能随增龄逐渐减退，而中心动脉反射波增强指数呈增高的趋势；肾功能及中心动脉反射波增强指数的增龄改变存在性别差异（P ＜0．05）；各年龄组女性的中心动脉反射波增强指数较男性升高更为明显（P ＜0．05）；相关性分析结果显示 GFR与中心动脉反射波增强指数呈负相关（r ＝-0．127， P ＜0．05）。多元线性回归分析显示年龄、Alx是新疆哈萨克族人群GFR的影响因素（β值分别为-0．272、-0．137， P 均＜0．01）。结论在新疆哈萨克族健康成年人中，年龄和中心动脉反射波增强指数可能是肾功能衰退的影响因素，而与颈动脉内膜中层厚度无关。

Research on relationship between the renal function and central aortic reflective wave pressure augmentation index and carotid media thickness in Xinj iang Kazak healthy adults

Objective To explore the relationship between natural decline of renal function and central aortic reflective wave pressure augmentation index and carotid media thickness in Xinjiang Kazak healthy adults.Methods 546 clinical healthy Kazak inhabitants from Tacheng region,Xinjiang province were en-rolled.Their blood pressure,serum creatinine and other indicators were detected.GFR was calculated by the Chinese corrected MDRD equation.Central systolic blood pressure and augmentation index of all the cases were detected by Sphygmocor device,Carotid IMT was analyzed by ultrasonography.Results Renal funotion declined and central aortic reflective wave pressure augmentation index tended to increase with age.There were gender differences in central aortic reflective wave pressure augmentation index.In each group,central aortic reflective wave pressure augmentation index increased even more significantly in fe-males （P 〈0.05）.Correlation analysis showed that GFR and central aortic augmentation index reflected wave was a negative correlation （r=-0.127,P 〈0.05）.Multiple linear regression analysis showed that age and central aortic augmentation index reflected waves were the influence factors of GFR of Kazakh peo-ple （β=-0.272,β=-0.137,respectively,P 〈0.01）.Conclusion Age and central aortic augmentation index reflected waves were main factors affecting renal function in Xinj iang Kazak healthy adults,and has nothing to do with the strength of arterial intima-media thickness.