维吾尔族骨折患者愈合时间与血浆同型半胱氨酸水平关系的研究

目的 探讨维吾尔族（维族）、汉族骨折患者同型半胱氨酸（HCY）水平及高同型半胱氨酸血症与骨折愈合时间的关系。方法 选择366例骨折患者，其中汉族154例，维族212例，男性204例，女性162例，检测血浆同型半胱氨酸浓度，分析维、汉族患者同型半胱氨酸水平差异及同型半胱氨酸水平对骨折愈合时间的影响。结果 维、汉族骨折患者年龄、性别、职业、吸烟、骨折部位、骨折类型、骨折复位时间、骨折原因、有无合并伤、固定方式、术后康复依从性等差异无统计学意义（P〉0．05），维族患者的血浆HCY水平、高HCY血症患病率高于汉族患者，差异具有统计学意义（P=0．000）；维族患者骨折愈合平均时间长于汉族患者骨折愈合时间，差异具有统计学意义（P=0．000）。在维族患者中，高HCY患者骨折平均愈合时间长于正常HCY水平者，差异具有统计学意义（P=0．000）；经校正年龄、性别、职业、吸烟、骨折部位、骨折类型、骨折复位时间、骨折原因、有无合并伤、固定方式、术后康复依从性等因素后，维族患者骨折愈合时间与血浆HCY水平呈线性相关（r=0．784，P=0．000）。结论 维族骨折患者血浆同型半胱氨酸水平高于汉族患者；维族患者中，血浆同型半胱氨酸水平可能是影响患者骨折愈合时间的重要因素。

Research on the relationship between the level of plasma homocysteine and the healing time in Uyghur patients with fracture

Objective To investigate the homocysteine （HCY） levels of Uyghur and Han patients with fractures and the relationship between the high HCY and fracture healing time. Methods 366 patients with fractures were chosen, including 154 Han and 212 Uyghur, 204 male and 162 female. Plasma HCY concentration was detected. Dimensional differences between Uyghur and Han HCY levels, HCY levels on fracture healing time were analyzed. Results The differences of age, gender, occupation, smoking, fracture site, fracture type, reduction of the fracture time, fracture reason, with or without associated injuries, fixation methods, compliance with postoperative rehabilitation, etc. between Uyghur and Han patients with fractures were not statistically significant （P 〉0.05）. The plasma hcy level, high hcy hyperlipidemia prevalence rate of Uyghur patients were higher than that of Han patients. The difference was statistically significant （P=0.000）. The average fracture healing time of Uyghur patients was longer than that of Han patients. The difference was statistically significant （P = 0.000）. The fracture healing time of high hcy Uyghur patients was longer than that of the normal hcy group. The difference was statistically significant （P =0.000）. After adjusting the factors of age, sex, occupation, smoking, fracture site, fracture type, frac ture reduction time, fracture reason, with or without associated injuries, fixed, rehabilitation adherence and other factors, the fracture healing time in Uyghur patients was lated with plasma hcy level, the correlation coefficient （r = 0.784, P = 0.000）. Conclusion postoperative linearly correHCY levels in patients of Uyghur fractures were higher than that of Han patients; the plasma in Uyghur patients may be the important factors affecting fracture healing time of patients.