对羟基苯乙基-α-Ｄ-葡萄糖甙对小鼠天然杀伤细胞的体外影响

本文用［³H］TdR靶细胞释放法，观察了对羟基苯乙基-α-D-葡萄糖甙在体外对小鼠脾天然杀伤细胞(NK)活性的影响.结果表明， 对羟基苯乙基-α-D-葡萄糖甙能提高正常鼠的脾NK杀伤活性，显著提高环磷酰胺给药后的NK杀伤活性，减轻由地塞米松引起的NK活性低下，协同白细胞介素-2明显增强鼠脾细胞的NK活性，而且剂量与作用呈正比. 结果提示对羟基苯乙基-α-D-葡萄糖甙为中药女贞子中具有免疫活性的水溶性成分之一.

Effect of p-hydroxyphenethyl-α-D-glucoside on natural killer cell in mice in vitro

The effect of p-hydroxyphenethyl-α-D-glucoside ［p-HPG(α)］ isolated from the fruits of Ligustrum lucidum Ait. on natural killer(NK) cell activity in vitro was studied by ［³H］TdR target release assay. When murine splenocytes were cultured with p- HPG(α) at various concentrations (50, 25 and 5 μg·L^-1) alone or combined with interleuk-2. The cytotoxicity of NK was significantly increased. p-HPG(α) also had the ability to protect the NK activity from the inhibition induced by cyclophosphamide and dexamethasone, especially by cyclophosphamide. These results suggest that p-HPG(α) is one of the water- soluble compounds posssessing immunomodulating effect in Ligustrum lucidum Ait.