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| 慢性肾病合并矿物质与骨代谢紊乱的发病机制、临床诊断与治疗 | |
| 引用本文： | 潘海,刘金鑫,张岩. 慢性肾病合并矿物质与骨代谢紊乱的发病机制、临床诊断与治疗[J]. 中国临床药理学与治疗学, 2014, 0(6): 695-700 |
| 作者姓名： | 潘海 刘金鑫 张岩 |
| 作者单位： | 上海理工大学系统生物医学研究中心,上海200093 |
| 基金项目： | 上海市科学技术委员会资助（10PJ1407700） |
| 摘 要： | 慢性肾病（CKD）患者的血液钙、磷、甲状旁腺激素、维生素D、成纤维细胞生长因子-23、等生化因子的水平会发生异常，这不仅能导致长期的系统性并发症，还会引起骨矿物质代谢失衡，造成骨损伤，增加慢性肾病合并矿物质与骨代谢紊乱（CKD-MBD）的患病率和死亡率。本文对CKD-MBD的发病机制、临床诊断与治疗策略作一综述。 |
| 关 键 词： | 慢性肾病 骨代谢 矿物质 继发性甲状旁腺机能亢进 维生素D |
Pathogenesis,clinical diagnosis and treatment for CKD-MBD |
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| PAN Hai,LIU Jin-xin,ZHANG Yan. Pathogenesis,clinical diagnosis and treatment for CKD-MBD[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 0(6): 695-700 | |
| Authors: | PAN Hai LIU Jin-xin ZHANG Yan |
| Affiliation: | (Center for System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China) |
| Abstract: | The abnormal levels of calcium, phosphorus, parathyroid hormone, vitamin D, fibroblast growth factor-23 in the blood of patients with chronic kidney disease （CKD） will not only cause long-term systematic complications, but also lead to bone mineral metabolism imbalance and bone injury, and finally increase the risk of morbidity and mortality with CKD-MBD. In this review, we summarize the pathogenesis, clinical diagnosis and treatment strategy for CKD-MBD. |
| Keywords: | chronic kidney disease bone metabolism mineral secondary hyperparathyroid-ism vitamin D |
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