| 扑热息痛栓的生物利用度测定实验 |
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| 引用本文： | 洪淳赞 金长炼. 扑热息痛栓的生物利用度测定实验[J]. 延边医学院学报, 1989, 12(2): 97-100 |
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| 作者姓名： | 洪淳赞 金长炼 |
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| 作者单位： | 延边医学院卫生学教研室，延边医学院卫生学教研室，延边医学院卫生学教研室，延边医学院卫生学教研室 |
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| 摘 要： | 本文报道以半合成脂肪酸酯为基质,聚乙烯吡咯烷酮(PVP)作为吸收促进剂的扑热息痛检剂和不含PVP的同种栓剂及市售栓剂的体外释放率及家兔体内吸收率的实验观察.结果表明,含PVP的栓剂比不含PVP的栓剂和市售栓剂的体外释放速度及体内吸收率都快.
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| 关 键 词： | 扑热息痛 栓剂 醋氨酚 吸收 |
Measuring Test of Bioavailability of Acetaminophen Suppositories |
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| Hong Chunzan,et al. Measuring Test of Bioavailability of Acetaminophen Suppositories[J]. Journal of Medical Science Yanbian University, 1989, 12(2): 97-100 |
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| Authors: | Hong Chunzan et al |
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| Affiliation: | Deapartme nt of Hygiene |
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| Abstract: | This article reports an experimental observation of rate of release in vitro- and absorption of rabbits in vivo of three kinds of acetaminophen supposi- tories,: (1) suppositories with semisynthetic ester fatty acid as suppository and polyvingpyrrolidone(PVP)as a sorbefacient agent;(2)the same kind of supposito suppositories without PYP; (3)the market suppositoryy. The result show thatthe release rate in vitro and absorption rate in vivo of the acetaminophensuppositories containing PVP were faster than those of suppo- sitory without PVP and the market suppository. |
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| Keywords: | acetaminophen suppositories absorption |
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