血脂、颈动脉粥样硬化与缺血性脑血管病的关系

目的：探讨血脂、颈动脉粥样硬化与缺血性脑血管病的关系。方法：2001年6月-2004年12月在佛山市第一人民医院诊治的缺血性脑血管病患者为病例组，共1583例，其中男性902例（57．0％），女性681例（43．0％），年龄38～89岁，平均（60．02±10．35）岁；同时期保健科随机选取的400名健康体检人群作为对照组。将动脉粥样硬化斑块分为稳定型和不稳定型。记录血脂和颈动脉粥样硬化情况并进行对比分析。结果：Logistic回归分析表明，颈动脉斑块与年龄、高血压史和胆固醇水平有显著相关性。有高血压、糖尿病、血浆低密度脂蛋白-胆固醇（LDL-C）水平增高和吸烟史的患者，颈动脉狭窄发生率显著增高。病例组总胆固醇、三酰甘油和LDL-C与对照组有显著差异。缺血性脑血管病患者颈动脉粥样硬化发生率显著高于普通人群。结论：血脂异常和颈动脉粥样硬化是缺血性脑血管病的重要因素。

Relationship Between Lipid, Carotid Artherosclerosis and Ischemic Cerebrovascular Disease

Objective： To investigate the relationship between lipid, carotid atherosclerosis and ischemic cerebrovascular disease. Methods： The patients with ischemic cerebrovascular disease were selected from the First People＇s Hospital of Foshan, Guangdong, China from June 2001 to December 2004 as patient group. A total of 1583 patients were recruited, among them 681 （43.0%） were females, and 902 （57.0%） were males, mean age 60.02 ± 10. 35 （range 38 to 89 years）, and 400 healthy subjects were selected from the Health Care Department in the same hospital as control group, Their atherosclerotic plaques were divided into stable and unstable types. Lipid and carotid atherosclerosis were documented and their comparative analyses were performed. Results： Logistic regression analysis showed that carotid plaques were significant correlated with age, hypertension history and cholesterol levels, The incidence of carotid stenosis increased significantly in patients with hypertension, diabetes mellitus, increased levels of plasma low-density lipoprotein cholesterol （LDL-C） and smoking history, There were significant differences in total cholesterol, triglyceride and LDL-C between the patient group and the control group, qhe incidence of carotid atherosclerosis, in patients with ischemic cerebrovascular disease was significantly higher than that in the general population. Conclusions： Lipid abnormality and carotid atherosclerosis are an important factor for ischemic cerebrovascular disease.