结核性和恶性胸腔积液中白介素-2、白介素-8、肿瘤坏死因子α和干扰素γ的变化

目的观察胸腔积液中白介素-2(IL-2)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)在结核性和恶性胸腔积液中的含量及其对鉴别诊断的价值。方法测定并比较111例结核性、恶性、肺炎性及漏出液4组不同病因胸腔积液患者血清IL-2、IL-8、TNF-α和IFN-γ水平。结果结核性、恶性组患者胸腔积液和血清中的IL-8、TNF-α和IFN-γ水平显著高于漏出液组(P均<0.01);结核性胸腔积液组患者胸液中IL-8、TNF-α和IFN-γ含量明显高于恶性胸腔积液组(P均<0.05);结核性胸腔积液组患者血清中IFN-γ含量明显高于恶性胸腔积液组(P<0.05)。结论胸腔积液中IL-8、TNF-α和IFN-γ联检可能对结核性和恶性胸腔积液之间的鉴别都有较高的临床意义。

The changes of Interleukin-2 and interleukin-8 and tumour necrosis ffactor-α and interferon-γ of tuberculous and malignant pleural effusions

Objective It is to observe and compare the significance of interleukin-2(IL-2),interleukin-8(IL-8),tumour necrosis factor-α(TNF-α),and interferon-γ(IFN-γ) in pleural effusions for the diagnosis of tuberculous and malignant pleural effusions.Methods The effusion and serum levels of IL-2,IL-8,TNF-α and IFN-γwere measured in 111 patients with pleural effusion.Results The effusion and serum levels of IL-8,TNF-αand INFγ in tuberculous and malignant effusion patients were significantly higher than those pleural transudate patients(P<0.01).The levels of IL-8,TNF-αand IFN-γ in pleural effusion of tuberculous effusion were obviously higher than those with malignant effusion(P<0.05).The serum level of IFN-γ in tuberculosis pleural effusion was obviously higher than those with malignant effusion(P<0.05).Conclusion The determination of IL-8,TNF-α and IFN-γ levels in pleural effusions may be beneficial to identification of tuberculous and malignant effusions.