高密度脂蛋白胆固醇及其相关因子载脂蛋白A-I和血清淀粉样蛋白A与非糖尿病性冠心病的关系

目的 观察高密度脂蛋白胆固醇(HDL-c)相关因子载脂蛋白A-I(apoA-I)和血清淀粉样蛋白A(SAA)对非糖尿病性冠心病的影响.方法 应用酶联免疫吸附法分别检测冠心病组(94例)及对照组(86例)患者血浆中apoA-I和SAA,观察HDL-C,apoA-I及SAA和冠心病发病之间的关系,并与人口学因素、血脂和炎症...

High density lipoprotein cholesterol and its associated factors apoA-I and serum amyloid A in non-diabetic patients with coronary heart disease

Objective To investigate the effects of high density lipoprotein cholesterol （HDL-C） and its related factors, apolipoprotein A- I （apoA- I ） and serum amyloid A （SAA）, on the non-diabetic patients with coronary heart disease （CHD）. Methods One hundred and eighty consecutive patients were enrolled in this study, with 94 in CHD group and 86 in control group. The data on demography, lipid, and inflammation related factors were obtained from hospital records. Serum concentrations of apoA- I and SAA were measured by ELISA. The association of HDL-C, apoA- I and SAA with CHD was analyzed. Results There were more patients with hypertension, smoking, and early onset CHD history in CHD group than in control group. Compared with control group, the concentrations of triglyceride, lipoprotein, high-sensitivity C-reactive protein （hsCRP） and SAA were significantly higher in CHD group （P〈0.05）, while concentrations of HDL-C （P=0.000） and apoA- I （P=0.000） were significantly lower in control group （P〈0.05）. Logistic analysis showed that the unadjusted odd ratio （OR） for HDL-C, apoA- I and SAA in the presence of CHD was 0.125 （95%CI 0.039-0.397）, 0.012 （95%CI 0.001-0.99） and 1.166 （95% CI 1.054-1.291）, respectively. The associations between apoA- I and the presence of CHD remained strong, regardless of confounding variables. The association of HDL-C and SAA with the presence of CHD were lost after adjusting for lipid status and inflammation related parameters. Conclusion Decreased concentration of apoA- I is an independent risk factor for non-diabetic CHD. Change in apoA- I concentration can reflect the effects of HDL-C on CHD more accurately and effectively.