| 眼前段发育异常与相关基因 |
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| 引用本文： | 高莉,姜发纲. 眼前段发育异常与相关基因[J]. 眼科新进展, 2006, 26(7): 551-553 |
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| 作者姓名： | 高莉 姜发纲 |
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| 作者单位： | 430022,湖北省武汉市,华中科技大学同济医学院附属协和医院眼科 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 眼前段发育异常不仅累及眼前段组织结构的形态异常,还可能改变房水引流系统的代谢和生理,患者常伴随眼压升高,继而发生青光眼。与眼球发育有关的基因突变是造成这些异常的重要原因,而这些基因产物的信号转导通路又相互联系,形成复杂的网络体系。我们就眼前段发育相关基因的研究进行综述。
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| 关 键 词： | 眼前段发育异常 青光眼 基因 |
| 文章编号： | 1003-5141(2006)07-0551-03 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2006-04-21 |
Anterior segment dysgenesis and its related genes |
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| GAO Li,JIANG Fa-Gang. Anterior segment dysgenesis and its related genes[J]. Recent Advances in Ophthalmology, 2006, 26(7): 551-553 |
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| Authors: | GAO Li JIANG Fa-Gang |
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| Affiliation: | From the Department of Ophthalmology, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China |
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| Abstract: | Anterior segment dysgenesis (ASD) is involved in not only the structural and morphological abnormalities of anterior segment but also the changes of metabolism and physiology of ocular drainage system.Patients with ASD often have elevated intraocular pressure then resulting in development of glaucoma.Gene mutations related to eyeball development are important reasons for these abnormalities.Moreover,the signal transduction pathways of these gene products are intercommunicated with each other to form a complicated network.We reviewed the study of anterior segment development related genes. |
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| Keywords: | anterior segment dysgenesis glaucoma gene |
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