| 计算pA_2与pD_2的简化方法 |
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| 引用本文： | 罗晓星,柴玉波,谭月华.计算pA_2与pD_2的简化方法[J].第四军医大学学报,1990(2). |
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| 作者姓名： | 罗晓星 柴玉波 谭月华 |
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| 作者单位： | 第四军医大学药理学教研室，第四军医大学生物化学教研室，第四军医大学药理学教研室 1983年级学员 |
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| 摘 要： | 计算pA_2、pD_2的方法有数种,以查表法较简便,唯运算时需借助相应的函数表。作者以最小二乘法直线回归运算,分析该函数表,发现其函数变化有明显的数学规律,分别导出求pA_2及pD_2所需的3个和1个直线方程,取代庞杂的函数表,使pA_2,pD_2的计算更为简便,而且结果可靠。
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| 关 键 词： | 回归分析 剂量效应关系 药物 Van Rossum法 |
A Simplified Method for Calculating pA2 and pD_2 |
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| LUO Xiao-Xing,CHAI Yu-Be and TAN Yue-Hua.A Simplified Method for Calculating pA2 and pD_2[J].Journal of the Fourth Military Medical University,1990(2). |
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| Authors: | LUO Xiao-Xing CHAI Yu-Be and TAN Yue-Hua |
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| Institution: | LUO Xiao-Xing,CHAI Yu-Be and TAN Yue-Hua Department of Pharmacology |
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| Abstract: | There are several methods for calculating pA2 and pD2, in which Van Rossum's method is an accurate one. However, function tables used in this method are inconvenient and time-consuming. In this study, the function tables were analysed. From that, we proposed 3 linear regression equations in stead of the function tables which were used for looking up log (X-1) and one linear equation substituting for the table used for log CAD. When this simplified method was compared with Van Rossum's method, we found that the results treated by two different ways we' e about the same and proved that the linear regression equations were reliable. |
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| Keywords: | regression analysis! dose-response relationship drug Van Rossum's method |
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