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Pharmacological profiles of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) on the mouse vas deferens preparation |
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| Authors: | Susan J. Ward P.S. Portoghese A.E. Takemori |
| Affiliation: | Departments of Pharmacology and Medical Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, U.S.A. |
| Abstract: | The profiles of action of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) have been assessed in the mouse vas deferens preparation. β-FNA, but not β-CNA, demonstrated a reversible agonist action that appeared to be mediated via κ-receptor interaction. β-CNA produced an irreversible antagonism of μ-, κ- and δ-mediated agonist actions, whereas β-FNA irreversibly antagonized μ-mediated agonist effects only. This selective action of β-FNA could also be seen following administration in vivo. β-CNA and particularly β-FNA should prove valuable in the elucidation of multiple opioid receptors. |
| Keywords: | β-FNA β-CNA Mouse vas deferens Multiple receptors Selective antagonism |
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