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Candida albicans and Enterococcus faecalis in the gut
Authors:Danielle A Garsin  Michael C Lorenz
Affiliation:Department of Microbiology and Molecular Genetics; University of Texas Health Science Center; Houston, TX USA
Abstract:
The fungus Candida albicans and the gram-positive bacterium Enterococcus faecalis are both normal residents of the human gut microbiome and cause opportunistic disseminated infections in immunocompromised individuals. Using a nematode infection model, we recently showed that co-infection resulted in less pathology and less mortality than infection with either species alone and this was partly explained by an interkingdom signaling event in which a bacterial-derived product inhibits hyphal morphogenesis of C. albicans. In this addendum we discuss these findings in the contest of other described bacterial-fungal interactions and recent data suggesting a potentially synergistic relationship between these two species in the mouse gut as well. We suggest that E. faecalis and C. albicans promote a mutually beneficial association with the host, in effect choosing a commensal lifestyle over a pathogenic one.
Keywords:Candida  Enterococcus  C. elegans  microbiome  hyphal morphogenesis
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