Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer |
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| Authors: | Jipei Liao Lei Yu Yuping Mei Maria Guarnera Jun Shen Ruiyun Li Zhenqiu Liu Feng Jiang |
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| Affiliation: | (1) Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA;(2) Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA;(3) Division of Biostatistics of The University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA |
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| Abstract: | ![]()
Background Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy. Molecular analyses of clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in tumorigenesis and could be developed as biomarkers for cancer. Here we aimed to develop small nucleolar RNAs (snoRNAs), a common class of ncRNAs, as biomarkers for NSCLC early detection. The study comprised three phases: (1) profiling snoRNA signatures in 22 NSCLC tissues and matched noncancerous lung tissues by GeneChip Array, (2) validating expressions of the signatures by RT-qPCR in the tissues, and (3) evaluating plasma expressions of the snoRNAs in 37 NSCLC patients, 26 patients with chronic obstructive pulmonary disease (COPD), and 22 healthy subjects. |
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